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Similarly, Mehdizadeh et al

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Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

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Although targeting oxidative stress is theoretically logical, most strategies currently employed in the clinical setting have failed to improve patient prognosis