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Via screening 18 HDACs for the potential delactylase activity, Zhao and colleagues reported that HDAC1-3 and SIRT1-3 could cleave L-lactyllysine marks in vitro [95], especially for nuclear HDAC1-3 serving as the most robust delactylases, suggesting a critical role of HDAC1-3 for the removal of histone lactylation [95]

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3.2 Mechanisms of resistance to membrane-targeting antifungals: polyenes and azoles 3.2.1 Polyene antifungal antibiotics interact with cell membrane sterols Polyene antifungal agentssuch as nystatin, AMB, and natamycinare broad-spectrum drugs commonly used to treat opportunistic fungal infections caused by Candida , Cryptococcus , Aspergillus , and Lentinus species (Tugume et al., 2023

The -opioid receptor antagonist naltrexone has been trialled for MUD on the premise that it will diminish the rewarding properties of methamphetamine [26]