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- Purity and origin are also important, 75% Dutch glutathione

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Hepatology 35 , 898904 (2002)

This enzymatic defect reduces synthesis of glutathione and the resulting low intracellular glutathione levels remove the normal tonic inhibition of the enzyme -glutamylcysteine synthetase (Figure 1 and Figure 2, reaction 4)

Such changes in turn leads to weakened SCN output, impaired photic entrainment, and loss of temporal coherence across organ systems