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In hypoxia reduced expression of EAAT1 and 2 contributes to increase extracellular glutamate concentration leading to neuronal overexcitation and excitotoxicity (Rossi et al., 2007
10.1056/NEJMoa2313906 11 DaiH.ZhaoK.ZhaoY.JiangK.HangZ.HuangX.et al (2025)
2013 Oct;25(10):1939-48
They are phagocytosed by macrophages as foreign particles and recognized by Toll-like receptors 2 and 4 (TLR2/TLR4), which subsequently activate and oligomerize the NLRP3 complex
Nat Rev Cancer (2010) 10:18193
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