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Cadmium in the environment enters the human body primarily through inhalation, ingestion, and dermal exposure, with the most concerning exposure route being through contaminated food, particularly crops grown in cadmium-rich soils (52)

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Through the Undiagnosed Disease Network, multiple other loss-of-function heterozygous Gdf11 mutations were subsequently identified in patients with multi-system defects including neurological, cardiovascular, or ocular phenotypes [6]

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More and more studies revealed versatile regulatory functions of glutathione in cell proliferation, apoptosis, immune functions, and skin melanogenesis