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immunohistochemistry showed that BNIP3L/NIX levels in these cells were significantly decreased in aged mouse cochlea, accompanied by increased expression of TOMM20, p62, and LC3B, which indicates an accumulation of dysfunctional mitochondria and a lack of mitophagy (Kim et al., 2021)

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This study demonstrates that treatment with antioxidants or activation of oncogenes such as ERBB2, PIK3CA or AKT can rescue ROS-induced cell death caused by detachment of mammary cells from the extracellular matrix

Thus, foam cells play a complex role in pulmonary fibrosis development, contributing to disease progression through regulation of immune responses and lipid metabolism