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B12 absorption declines with age (4)

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Both antibodies are effective in treating relapsed/refractory MM and can be used in combination with other therapies 148,149

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Recent reports have shown that the shear-induced opening of endothelial Piezo1 channels activates the calcium-dependent protease calpain (Li et al., 2014), which in turn cleaves talin (a protein that links membrane integrins to the actin cytoskeleton) to alter integrin-mediated cell adhesion (McHugh et al., 2010)