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For example, too much vitamin B6 may cause severe skin lesions, along with other symptoms like numbness, digestive issues, and poor muscle control, according to Mayo Clinic

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This is especially true for gastrointestinal issues such as: Acid reflux Gastric irritation Ulcer-related discomfort Animal studies on gastric ulcers have shown visible healing within 7 to 14 days, with significant reduction or complete closure of lesions

However, rare cases of fulminant hepatic necrosis and hepatic failure have been reported

Ther Adv Psychopharmacol 2(6):241254 Azadbakht AA, Mashayekhi-Sardoo H, Baghcheghi Y (2025) Molecular mechanisms underlying chronic high-dose ketamine-induced apoptosis in the hippocampus: a narrative review

[1] Vitamin C enhances the absorption of polysaccharides in Reishi