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Finally, like the brain, Cry1 expression appeared to be slightly higher relative to Cry2 expression in the lens

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Though smFRET was demonstrated for the first time by Ha et al., in 1996 by obtaining simultaneous dual color images and emission spectra from donor and acceptor fluorophores linked by a short DNA molecule (Ha et al., 1996), the first actual application of this tool in analysis of IDPs was reported in 2007 by Mukhopadhyay et al., who demonstrated that the natively unfolded yeast prion protein adopts an ensemble of collapsed and rapidly fluctuating structures (Mukhopadhyay et al., 2007)

In addition to its role in metabolic tissues, some of the beneficial effects of PPAR ligands are due to anti-inflammatory actions, including inhibition of pro-inflammatory cytokines such as interferon gamma (IFN) and tumor necrosis factor-alpha (TNF) [53,54], increase of anti-inflammatory cytokines, and inhibition of inducible nitric oxide synthase (iNOS) expression

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