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However, these agents have not yet been studied in human clinical trials specifically in the context of kidney health

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The mitochondrial heat shock proteins belonging to the chaperonin family, Hspd1 (Hsp60) and Hspe1 (Hsp10), both promote the proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix 38

They found that DDD therapeutically targets AS by enhancing mitochondrial function through the HIF-1 signaling pathway, reducing ROS levels, and modulating GPX4, Bcl2, and Bax protein levels, thereby benefiting AS and hyperlipidemia (Wu et al., 2023a)

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