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It promotes healing through several mechanisms: 1

10.1016/j.cmet.2012.12.011

3.5.2 Methotrexate-induced renal injury Methotrexate (MTX), a potent anti-metabolite and folate antagonist, is administered at elevated doses for the treatment of various cancers, while lower doses are utilized for managing non-malignant conditions ( 3.5.3 Doxorubicin-induced renal intoxication Doxorubicin (DOX), a chemotherapeutic agent classified as an anthracycline, is a highly effective therapeutic used in the management of various hematological cancers and solid tumors (Tangpong et al., 2011)
Lucesoli, F., Caligiuri, M., Roberti, M

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In regulating ChaC1 expression, C/EBP- has been observed to recruit ATF4 to the ChaC1 promoter in response to ER stress (48)
