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The NADPH produced via the pentose phosphate pathway, as well as through several additional pathways, is required for a variety of reductive biosynthetic reactions as well as for the regeneration of the reduced form of glutathione (GSH) from the oxidized (GSSG) form

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doi: 10.2147/COPD.S309129

These may include gastrointestinal issues, allergic reactions, or skin rashes

A randomized phase II clinical trial showed that this antibody in combination with epirubicin, cisplatin, and capecitabine (ECX) could prolong PFS in advanced gastric cancer patients relative to the control group, especially in patients with high c-Met expression ( Onartuzumab is a recombinant humanized anti-c-Met monoclonal antibody, which is produced in Escherichia coli (Shah et al., 2016)