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However, another clinical trial found that an 8-week course of curcumin with piperine did not significantly reduce serum pro-oxidantantioxidant balance (PAB) values, suggesting that the administered dose may have been insufficient to achieve a measurable reduction in oxidative stress (Table 4)

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however, acivicin also inhibits enzymes in purine and pyrimidine biosynthesis, which may be its actual mode of action (Poster et al., 1981