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IR injury also triggered substantial elevations in apoptotic markers (271% increase in Bax (Bcl2-associated X protein) and 65.9% decrease in BCL2 (B-cell lymphoma 2), and inflammatory mediators (285.7% increase in NFB (nuclear factor-kappa B)

On the contrary, in adult male rats treated with 25 g/kg/week AFB1 for 8 weeks, AFB1 could trigger obvious neurotoxicity, inflammatory responses, oxidative stress and, anxiety and depression-like behaviors (241)

So, one distinction here is TB-500 is not orally active

10.1021/acsomega.9b02663 148 JinD.DaiK.XieZ.ChenJ

Ferrozine competition assay All solutions were prepared in 50 mM HEPES (pH 7.5) under oxygen-free conditions in an anaerobic glovebox (Coylab)

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