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In reality, however, many antioxidant compounds suffer from poor absorption, rapid clearance, limited tissue penetration, and inadequate retention, all of which compromise target engagement (Yang et al., 2019)

D.PickarD.et al (1996)

doi: 10.1016/0163-7258(90)90064-9

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In addition, some attempts to estimate the solubility of sulfonamides in different aqueous or organic media have been reported in the literature (15-17)

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