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Haddad M, Stewart J, Xie P, et al

Introduction Diabetes mellitus (DM, abbreviations are defined in Table 1) is a major public health problem worldwide, which imposes heavy economic and medical burdens on patients and healthcare systems [1, 2]

As a negative control, the highly conserved Lys residue (K391) required for CRK kinase activity in the ATP-binding domain of OsVIRK1 was mutated to Glu residue (E391) to produce the MBP-VIRK1C K391E protein

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Wnt/beta-catenin signaling in development and disease