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Pathogenesis correlates with neurodegeneration, apoptotic neuronal loss, or synaptic transmission deficits, manifesting as cognitive decline, motor impairment, and sensory processing abnormalities

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A transition state analog has been tested in vitro , which exhibits nano-molar affinity to ASNS and has relatively high selectivity against other SD-containing enzymes in the HCT-116 cell line (Figure 5F) (Zhu et al., 2019)

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[DOI] [PMC free article] [PubMed] 76.Iguchi H, Nishina T, Nogami N, Kozuki T, Yamagiwa Y, Yagawa K

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