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Glutathione is the most abundant non-protein thiol (compounds containing R-SH) in animal cells, with concentrations ranging from 0.5 to 10 mmol/L

The net log2 fold up-regulation of GST genes in pathogen-inoculated Tx7000 was 120 while the net log2 fold down-regulation of GST genes in pathogen-inoculated SC599 was 11.6

Environ Sci Pollut Res 26:1926119271

Pezantes-Orellana C, German Bermdez F, la Matas De Cruz C, Montalvo JL, Orellana-Manzano A

As expected, the transdifferentiation process was inhibited in SC-islets treated with both trans-ISRIB and ZnPTO, as evidenced by a reduced proportion of SC- cells compared with that in SC-islets treated with ZnPTO alone (Fig

Proposed mechanisms include oxidative stress, mitochondrial dysfunction, dyslipidaemia, and genomic modulation of hypertrophic and fibrotic signalling pathways (70)