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The S9 Nonclinical Evaluation for Anticancer Pharmaceuticals published by the ICH provides additional guidance for an empirical method for cytotoxic agents with a very small therapeutic window (i.e., very steep concentrationsafety curve).8 Due to the acceptance of greater safety risk in patients with cancer to achieve a therapeutic benefit, the startingdose calculations are based on a dose and regimen that has elicited some toxicity in animals provided it is not a severe, irreversible toxicity
T1 may promote immune tolerance and regulation, allowing the body to better encourage proper immune response rather than broadly suppressing the immune system
We found that in mammalian brain, the absence of endogenous parkin is compensated by the following redox indices: an elevation in GSH concentrations
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Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes
IKK -targeted anti-inflammatory activities of a butanol fraction of artificially cultivated Cordyceps pruinosa fruit bodies
