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In T2D, FA spillover from adipocytes increases hepatic acetyl-CoA, an allosteric regulator of pyruvate carboxylase activity, resulting in greater gluconeogenesis in the liver (183, 200)

[DOI] [PubMed] [Google Scholar] 18.Ortancil O., Sanli A., Eryuskel R., Basaran A., Ankarali H.A

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In preclinical data, the pair improves adipocyte NAD+ by inhibiting NNMT, resulting in better fat metabolism and reduced obesity.[8][3] For anti-aging, this translates to improved tissue resilience and reduced senescence