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Blockade of IL-17 signaling pathway effectively reverses alcohol-associated hepatic injury and compulsive drinking behaviors in dependent mice [140, 235], suggesting therapeutic potential of inflammatory cytokine targeting along the brain-liver axis

However, treatment with the copper chelator BCS resulted in an increase in the correlation between calcium transients, which reflect synchronized action potentials produced by neurons in the circuit (Mao et al., 2001)

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The immunohistochemical analysis of the SN also verified that the presence of NanoCA protected dopaminergic neurons, validating the anti-PD activity of NanoCA (Fig