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Western blot analysis of C-CASP3 protein was consistent with the above results, i.e., the expression level of C-CASP3 was significantly reduced in the peroxynitrite + ebselen group, while it was significantly increased in the peroxynitrite + gpx1 / group compared with the peroxynitrite-only group (Figure 4C)

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The misfolding and aggregation of mutant ataxin-3 protein contribute to the neuronal dysfunction and degeneration, primarily affecting the cerebellum, brainstem, and basal ganglia 93,94

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