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Translocation of a gut pathobiont drives autoimmunity in mice and humans
Sometimes animal experiments make use of supraphysiologic doses or intraperitoneal route, which cannot be directly scaled to humans [115, 288]
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Furthermore, ERK1/2 phosphorylates and activates the transcription factor ETS2, which upregulates the expression of CYP27A1, an enzyme that modulates lipid metabolism and suppresses CD8 + T cell function via liver X receptor beta (LXR) signaling
de Herder, W
