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In this study, B12 levels were 244 pmol/l or more in all patients at baseline, but in those who improved, B12 levels almost quadrupled, whilst in non-responders B12 levels went up by only 50%

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No Tolerable Upper Level has been set for B12 in the UK due to its low toxicity, though serious adverse reactions, while rare, are possible

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When reconstituting a lyophilized vial, direct the stream of water down the side of the vial, not directly onto the powder