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Notably, this regimen represents a breakthrough in treating patients with liver metastases, achieving a 50.0% objective response rate in this subgroup (98)

doi: 10.1093/stmcls/sxac027

This activation promotes synaptogenesis, neurogenesis, and neuronal survival by mimicking or potentiating brain-derived neurotrophic factor (BDNF)-like activity, enhancing synaptic connectivity and cognitive plasticity