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Although preclinical and clinical data have confirmed that such compounds have significant preventative neuroprotective activity in oxaliplatin-induced CIPN [83,84,85,86], it is hypothesized that neuroprotection from calmangafodipir may also be possible with other chemotherapeutics [4, 64]

In an in-vivo study on human skin by Kang et al, 43 researchers evaluated whether the antioxidant activity of NAC could inhibit responses to UV light exposure, a primary cause of photoaging in the skin of humans

Therefore, the essential source of L-serine for the brain is its synthesis from 3-PG and the major consequences of primary defects of L-serine synthesis are disorders of brain development and function [51,52]

sativum fruit extract (CSE), which contains quercetin and kaempferol-3O-glucoside, reduces LPS-induced nitric oxide (NO) production and inhibits the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated BV-2 microglial cells

These mechanisms underscore the significant role of natural products in the treatment of brain disorders
