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We dont know whether any of these factors cause or prevent EGIDs

Additionally, recent research shows that cystathionine -lyase (CSE) drives astrocytes toward a neurotoxic phenotype in PD by forming a complex with Yes-associated protein (YAP), which activates Forkhead box D3(FOXD3)-mediated transcription of neuroinflammation-related genes (Zhu et al., 2024)

10.1101/2024.10.11.617524(Accessed March 7, 2025)

128 VigilanzaP.AquilanoK.RotilioG.CirioloM

doi: 10.3148/cjdpr-2016-023

In transgenic mice, MnSOD overexpression or treatment with MnSOD mimetics mitigates ischemia/reperfusion injury and improves neurological outcomes [204,205]