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Moreover, the potential of personalized medicine in managing oxidative stress-related neurodegeneration is gaining momentum: genetic variants in the Nrf2 signaling pathway or SIRT1-mediated deacetylation affecting astrocytic GSH synthesis (e.g., regulating glutamate cysteine ligase catalytic subunit expression), combined with biomarkers like individual GSH levels and Nrf2 activity, could enable tailored interventions

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Virus-like particle immunotherapy or vaccines against SLC7A11 have been developed and shown to reduce the metastatic potential of breast cancer cells (Bolli et al., 2018
