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Mar 2014;101(3):759-66

Exclusion criteria were patients with metabolic disorders, infective endocarditis, heart failure, children with renal and hepatic diseases, and the administration of drugs with anti-inflammatory or antioxidant effects

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Longitudinal studies have shown that while infancy is marked by rapid microbial succession, the gut microbiome generally reaches a stable, adult-like configuration by approximately 23 years of age (Yatsunenko et al., 2012