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It is important to note that weight loss in ALS patients is thought to occur independently of swallowing difficulties (dysphagia) and is not fully explained by denervationinduced muscle atrophy (Guillot et al

Organic solvents, including alcohol and its metabolites, are known to impair TJ barriers and emulsifiers present in processed foods can alter the composition of the intestinal microbiota, encouraging bacterial encroachment beyond the mucous layer that may lead to epithelial inflammation and damage (Vojdani 2014

Glyceroneogenesis is inhibited through HIV protease inhibitor-induced inflammation in human subcutaneous but not visceral adipose tissue

Declaration of Interest SJ has no conflicts of interest to declare

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