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Bcl2 and mir-15/16: from gene discovery to treatment

Dont go it alone

Thus, angiogenesis is a process that is central not only to development but also in many diseases

Mechanistically, hyperactivation of Drp1 suppresses hexokinase 1 (HK1), a glycolytic enzyme localized to the mitochondria, inducing metabolic reprogramming that promotes NLRP3-driven inflammation and oligodendrocyte pyroptosis (Pradeepkiran and Reddy, 2020

This is followed by an infiltration of sensitised T-lymphocytes, which recognise the antigen and release cytokines to produce local inflammation, oedema and irritation

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