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One major factor is oxidative stress

Enhance Sleep Quality and Combat Fatigue: Glutathione is a powerful antioxidant that can lower inflammation, positively impact the central nervous system, and transform your overall health and well-being

Sayin VI, Ibrahim MX, Larsson E, Nilsson JA et al (2014) Antioxidants accelerate lung cancer progression in mice

Moreover, advanced light-dark schedules in genetically predisposed mice (e.g., K-ras/p53 mutants) led to enhanced tumor growth and cell proliferation with increased oncogene c-Myc expression, while clock gene knockouts have tumor suppressive effects 203

This margin of safety provides reassurance, though caution remains appropriate given the limited formal human studies