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It is one of the few known metabolic enzymes that are dysregulated in cancer ( 3.1.2 p53 The tumor suppressor gene TP53 (aka, p53) encodes the protein p53, a crucial regulator of cellular metabolism

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Altered S-nitrosothiol homeostasis provides a survival advantage to breast cancer cells in HER2 tumors and reduces their sensitivity to trastuzumab

It is well documented that GSTs conjugate GSH to an array of electrophilic compounds of exogenous and endogenous origins (Perperopoulou et al., 2017)