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Elevated ceramide levels, which are associated with cognitive decline and brain atrophy, are notable in aging individuals and patients with AD [12]

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The GSSG/GSH redox couple plays a vital role in several enzymatic reactions, including the elimination of peroxides by GSH peroxidases (GPx), in covalent addition of cysteines to proteins by glutaredoxin , and in detoxification of electrophiles by GSH-S-transferase (GST) 585,586,587