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Collectively, these findings suggest that the transmission of peripheral inflammation to the central nervous system, and its self-sustaining nature within the brain, may constitute a central potential mechanism linking acute exacerbations of PEM with long-term cognitive consequences

In vitro studies have demonstrated that the structure has good hygroscopicity, large porosity and great biocompatibility

Selenoprotein P is also important for intercellular transport of Se, especially to the brain, and in controlling inflammation, and colitis-induced tumorigenesis (4850)

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Encapsulation occurs through passive loading during formation, active loading using pH gradients, or direct lipid bilayer integration for lipophilic compounds

This pathway also provides NADH, which is important as a cofactor of methemoglobin reductase to regenerate oxidized Hb to its reduced functional state