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Funding The author(s) declared that financial support was not received for this work and/or its publication

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Under these conditions, treatment with the synthetic supersulfide donor N -acetylcysteine tetrasulfide (NAC-S2) significantly elevated intracellular levels of LWM supersulfides

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Inhibitors 6 - 8 were incubated with TGR with and without NADPH, and the inhibition of TGR activity was determined after adding a second aliquot of NADPH and 5,5-dithiobis (2-nitrobenzoic acid) (DTNB)

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