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High consumption of ultra-processed or contaminated foods also promotes oxidative damage

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Depletion of bioavailable nitric oxide in the vasculature by excess oxidants causes endothelial dysfunction, which is characterized by a decrease in endothelium-dependent vasodilation while retaining the ability of vascular smooth muscle cells to vasodilate in response to nitric oxide donors, such as sodium nitroprusside [53]

Spinelli S, Ballard T, Feldon J et al (2006) Enhancing effects of nicotine and impairing effects of scopolamine on distinct aspects of performance in computerized attention and working memory tasks in marmoset monkeys

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