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However, the up to 60% increase in total glutathione in infested resistant plants could not be simply explained by increased stability of glutathione, since Hessian fly did not downregulate genes encoding the putative glutathione degradation enzymes (Figure 5)

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Another study linked type 2 diabetes-associated variants in MAP3K5 to transcriptomic changes in human islets under stress, suggesting that genetic risk factors can predispose beta cells to dysfunction in response to metabolic and inflammatory challenges [20]