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Individual Sensitivities Everyone's biochemistry is unique
PubMed Central, Lahner, Edith, et al

4.4.3 Nose-to-brain delivery Intranasal drug delivery has been recognized as a promising non-invasive strategy for CNS targeting in AD because it may enable nose-to-brain transport through olfactory and trigeminal pathways

Thus, there were increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy in glaucomatous rats [11]

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