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Hence, riboflavin supplementation in patients with GFER mutations may potentially have clinical benefit, but this is speculative

In a dose escalation study of ADI-EGP20 together with cisplatin and pemetrexed in thoracic cancer patients, sustainable arginine depletion was observed in all patients and neutralizing antibodies level was much lower compared to ADI-PEG20 mono therapy or ADI-PEG20, docetaxel combinational therapy [143]

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Nutritional supplements should not be used to replace a balanced diet

It represents a promising first-line treatment for DPN, preventing early development and progression through both direct and indirect antioxidant effects [8,23,71,87,110] (Figure 3)