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To enhance therapeutic efficacy and minimize risks, future research should explore selective targeting of TNFR1 or activation of the TNF/TNFR2 pathway, which may provide a safer and more effective means of suppressing inflammation (95)

and Bonhoeffer T (2001) Morphological changes in dendritic spines associated with long-term synaptic plasticity Annu Rev Neurosci 24: 1071 -89

activates TrkB, TrkA, and GFR1 receptors

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These are commonly used during seasonal stress or periods of increased exposure