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Annual B12 screening is recommended for individuals on long-term Metformin therapy, especially those on high doses or taking proton pump inhibitors

Jabbing the needle quickly is more comfortable than doing it slowly

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More importantly, the PGI-R directly assesses the degree of improvement, whereas the other assessment tools only indirectly assess the degree of improvement by calculating a small difference between two large numbers (initial and final), which leads to a greater uncertainty in the degree of improvement