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used a repository of transcriptional responses to compounds, the Connectivity Map (cMap) [60], and MANTRA software ( to explore networks of compounds producing similar transcriptional responses

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The pharmacokinetics of tirzepatide after a single 5 mg dose was evaluated in patients with different degrees of hepatic impairment (mild, moderate, severe) compared with subjects with normal hepatic function [see Use in Specific Populations (8.7)]