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Understanding these distinctions helps clarify their roles in medical and pharmaceutical applications

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While GPx activity remained stable in both tissues during hypoxia, GST activity showed substrate-dependent responses: no change with the artificial substrate CDNB but a significant decrease with the physiological lipid peroxidation product 4-HNE, particularly in erythrocytes

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Without baseline and on-treatment measurements, the benefit of adding glutathione remains speculative

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In a follow-up study, homocysteine and GPx1 were the strongest predictors of future cardiovascular event risk, and those with low GPx-1 activity had a nearly 3-fold increase in risk if they also had homocysteine levels above the median [87]

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doi: 10.1136/thx.2009.121459

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In 2021, Antonia Tnase et al

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