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Maruthur NM, Tseng E, Hutfless S, et al

doi: 10.1007/s10522-008-9177-z

In addition, the photoreceptor cells in diabetic mice also showed enhanced levels of iron, ROS, and MDA and reduced GSH concentration with downregulation of GPX4 and SLC7A11, and upregulation of ACSL4, FTH1 and NCOA4, which suggested that ferroptosis is also involved in the pathogenesis of photoreceptor degeneration in the development of the early stages of DR (Gao et al., 2023)

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It has been estimated to affect ~1% of the general population in the United States according to the Center for Disease Control and Prevention (CDC), and women are affected at a rate 3 times higher than men (42, 109)