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Baek, A

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Clock-controlled output genes modulate a myriad of metabolic and cellular functions, such as the regulation of energy balance, DNA-damage repair and xenobiotic detoxification in both mammals [9][11] and Drosophila [12][14]

On the other hand, animal models suggest that a simple genetic defect (such as TREX1 deficiency) may be insufficient to induce full tissue inflammation, often requiring an environmental 'second hit', indicating that its pathogenicity may be conditional rather than absolutely causative (217)

Glide SP conducts a thorough sampling of the remaining ligands with a more accurate scoring function to refine the binding poses
