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The most common culprit is a herniated or slipped disc in the lumbar spine

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Lancet Neurol 15:12571272 Bae E-J, Lee H-J, Rockenstein E, Ho D-H, Park E-B, Yang N-Y, Desplats P, Masliah E, Lee S-J (2012) Antibody-aided clearance of extracellular -synuclein prevents cell-to-cell aggregate transmission

In recent years, emerging studies have found that SFN affects the metabolism of glucose and lipids in the liver, and could improve insulin resistance and reduce hepatic lipid accumulation

This reduction in enzymatic activity and compromised ROS detoxification might contribute to an elevated oxidative stress environment within the cell (Mirsadraee and Saadat, 2019)

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