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A thorough understanding of the shortcomings of past clinical programs will enable the development of novel melanocortin therapeutics for the treatment of general obesity

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doi: 10.1093/eurheartj/ehab551 95 ChapmanMJGinsbergHN

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One possible explanation for this finding is pancreatic necrosis and exhaustion of acinar cells, thereby decreasing the amount of lipase leaking from the acinar cells into the vascular space, but further morphological and ultrastructural studies in dogs with similar findings are needed to evaluate this hypothesis further