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We simulated the effect of pifithrin- treatment by multiplying the phospho-p53-dependent production of p21 and MDM2 with k PFT = 0.5, and the amount of phospho-p53 and the phosphorylation rate of p53 with k PFT phos = 0.67 at the time of treatment, because the effect of pifithrin- causes approximately a 50% decrease in p53-dependent transcriptional activation 95 and a 33% decrease in phosphorylated p53 species 93

We conclude that the essential reason Hcy maintains homeostasis over such a large range of is a relatively low value of in the model

Begley, D

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Eligibility also extended to participants who were already receiving stable doses of preventive medication for migraine