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Deficiency in vitamin B6 is commonly linked to malnutrition, alcoholism, malabsorption syndromes, or as an adverse effect of certain medications, such as cyclosporine, hydralazine, cycloserine, penicillamine, isoniazid, levodopa, phenelzine and chemotherapy treatments (, , , )

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The mapping, as well as the calculation of the percentages of methylation of cytosines in CG context were performed with the Bismark software ( CCL3 functional annotations, such as transcription start site, single nucleotide polymorphisms and predicted transcription factor binding sites were identified with the UCSC Genome Browser ( Statistical analysis Statistical analyses were performed using GraphPad Prism software (version 8.0.2) (GraphPad Software Inc., Irvine, CA)